| Title | A bioactive polyacetylene compound isolated from Centella asiatica. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Govindan, G, Sambandan, TG, Govindan, M, Sinskey, A, Vanessendelft, J, Adenan, I, Rha, CK |
| Journal | Planta Med |
| Volume | 73 |
| Issue | 6 |
| Pagination | 597-9 |
| Date Published | 2007 Jun |
| ISSN | 0032-0943 |
| Keywords | Animals, Antineoplastic Agents, Phytogenic, Apoptosis, Cell Line, Tumor, Centella, Humans, Mice, Phytotherapy, Plant Extracts, Polyynes |
| Abstract | A polyacetylene compound was isolated from the aerial parts of Centella asiatica. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)-2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63%) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 microM (IC (50) = 24 +/- 2 microM) in 24 hours. The compound also reduces nitric oxide production by 70 +/- 2% in lipopolysacharride-activated mouse macrophages at 24 microM with no measurable cytotoxicity. |
| DOI | 10.1055/s-2007-981521 |
| Alternate Journal | Planta Med |
| Citation Key | 93 |
| PubMed ID | 17520525 |