A bioactive polyacetylene compound isolated from Centella asiatica.

TitleA bioactive polyacetylene compound isolated from Centella asiatica.
Publication TypeJournal Article
Year of Publication2007
AuthorsGovindan, G, Sambandan, TG, Govindan, M, Sinskey, A, Vanessendelft, J, Adenan, I, Rha, CK
JournalPlanta Med
Date Published2007 Jun
KeywordsAnimals, Antineoplastic Agents, Phytogenic, Apoptosis, Cell Line, Tumor, Centella, Humans, Mice, Phytotherapy, Plant Extracts, Polyynes

A polyacetylene compound was isolated from the aerial parts of Centella asiatica. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)-2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63%) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 microM (IC (50) = 24 +/- 2 microM) in 24 hours. The compound also reduces nitric oxide production by 70 +/- 2% in lipopolysacharride-activated mouse macrophages at 24 microM with no measurable cytotoxicity.

Alternate JournalPlanta Med
Citation Key93
PubMed ID17520525