A bioactive polyacetylene compound isolated from Centella asiatica.

TitleA bioactive polyacetylene compound isolated from Centella asiatica.
Publication TypeJournal Article
Year of Publication2007
AuthorsGovindan, G, Sambandan, TG, Govindan, M, Sinskey, A, Vanessendelft, J, Adenan, I, Rha, CK
JournalPlanta Med
Volume73
Issue6
Pagination597-9
Date Published2007 Jun
ISSN0032-0943
KeywordsAnimals, Antineoplastic Agents, Phytogenic, Apoptosis, Cell Line, Tumor, Centella, Humans, Mice, Phytotherapy, Plant Extracts, Polyynes
Abstract

A polyacetylene compound was isolated from the aerial parts of Centella asiatica. The chemical structure of this new compound was identified as methyl 5-[(E)-9-hydroxy-1-(1-hydroxyhexyl)-2-methoxyundeca-3,10-diene-5,7-diynyloxy]pentanoate (cadiyenol). This compound induces apoptosis (63%) independent of cell cycle regimen in mouse lymphoma cells (P388D1) at 28 microM (IC (50) = 24 +/- 2 microM) in 24 hours. The compound also reduces nitric oxide production by 70 +/- 2% in lipopolysacharride-activated mouse macrophages at 24 microM with no measurable cytotoxicity.

DOI10.1055/s-2007-981521
Alternate JournalPlanta Med
Citation Key93
PubMed ID17520525