Cell engineering and molecular pharming for biopharmaceuticals.

TitleCell engineering and molecular pharming for biopharmaceuticals.
Publication TypeJournal Article
Year of Publication2008
AuthorsAbdullah, MA, Rahmah, AUr, Sinskey, AJ, Rha, CK
JournalOpen Med Chem J
Date Published2008 May 14

Biopharmaceuticals are often produced by recombinant E. coli or mammalian cell lines. This is usually achieved by the introduction of a gene or cDNA coding for the protein of interest into a well-characterized strain of producer cells. Naturally, each recombinant production system has its own unique advantages and disadvantages. This paper examines the current practices, developments, and future trends in the production of biopharmaceuticals. Platform technologies for rapid screening and analyses of biosystems are reviewed. Strategies to improve productivity via metabolic and integrated engineering are also highlighted.

Alternate JournalOpen Med Chem J
Citation Key103
PubMed ID19662143
PubMed Central IDPMC2709479