Title | Metabolic engineering--methodologies and future prospects. |
Publication Type | Journal Article |
Year of Publication | 1993 |
Authors | Stephanopoulos, G, Sinskey, AJ |
Journal | Trends Biotechnol |
Volume | 11 |
Issue | 9 |
Pagination | 392-6 |
Date Published | 1993 Sep |
ISSN | 0167-7799 |
Keywords | Biomedical Engineering, Biotechnology, Genetic Engineering, Metabolism |
Abstract | Attempts to improve the productivity of cellular systems or to increase metabolite yield often require radical alteration of the flux through primary metabolic pathways. However, achieving the desired result often proves difficult because the control architectures at key branch points have evolved to resist flux changes. Identification and characterization of these metabolic nodes is a prerequisite to rational metabolic engineering. |
DOI | 10.1016/0167-7799(93)90099-U |
Alternate Journal | Trends Biotechnol |
Citation Key | 162 |
PubMed ID | 7764086 |