Metabolic engineering--methodologies and future prospects.

TitleMetabolic engineering--methodologies and future prospects.
Publication TypeJournal Article
Year of Publication1993
AuthorsStephanopoulos, G, Sinskey, AJ
JournalTrends Biotechnol
Volume11
Issue9
Pagination392-6
Date Published1993 Sep
ISSN0167-7799
KeywordsBiomedical Engineering, Biotechnology, Genetic Engineering, Metabolism
Abstract

Attempts to improve the productivity of cellular systems or to increase metabolite yield often require radical alteration of the flux through primary metabolic pathways. However, achieving the desired result often proves difficult because the control architectures at key branch points have evolved to resist flux changes. Identification and characterization of these metabolic nodes is a prerequisite to rational metabolic engineering.

DOI10.1016/0167-7799(93)90099-U
Alternate JournalTrends Biotechnol
Citation Key162
PubMed ID7764086