Positive outcomes of oil palm phenolics on degenerative diseases in animal models.

TitlePositive outcomes of oil palm phenolics on degenerative diseases in animal models.
Publication TypeJournal Article
Year of Publication2011
AuthorsSambanthamurthi, R, Tan, YA, Sundram, K, Hayes, KC, Abeywardena, M, Leow, S-S, Sekaran, SDevi, Sambandan, TG, Rha, CK, Sinskey, AJ, Subramaniam, K, Fairus, S, Wahid, MBasri
JournalBr J Nutr
Date Published2011 Dec
KeywordsAnimals, Arrhythmias, Cardiac, Atherosclerosis, Blood Pressure, Diabetes Mellitus, Type 2, Disease Models, Animal, Male, Mice, Mice, Inbred BALB C, Nitric Oxide, Palm Oil, Phenols, Plant Oils, Rabbits, Rats, Rats, Inbred WKY

It is well established that plant phenolics elicit various biological activities, with positive effects on health. Palm oil production results in large volumes of aqueous by-products containing phenolics. In the present study, we describe the effects of oil palm phenolics (OPP) on several degenerative conditions using various animal models. OPP reduced blood pressure in a NO-deficient rat model, protected against ischaemia-induced cardiac arrhythmia in rats and reduced plaque formation in rabbits fed an atherogenic diet. In Nile rats, a spontaneous model of the metabolic syndrome and type 2 diabetes, OPP protected against multiple aspects of the syndrome and diabetes progression. In tumour-inoculated mice, OPP protected against cancer progression. Microarray studies on the tumours showed differential transcriptome profiles that suggest anti-tumour molecular mechanisms involved in OPP action. Thus, initial studies suggest that OPP may have potential against several chronic disease outcomes in mammals.

Alternate JournalBr J Nutr
Citation Key73
PubMed ID21736778
PubMed Central IDPMC4179496