Solving Large Problems With Small Biofactories

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2018

Koledova, Vera V, Park, Jennifer H, Rha, ChoKyun, Sambanthamurthi, Ravigadevi, Shin, Hyeari, Sinskey, Anthony J, Tan, Yew Ai, Weinberg, Robert P.

Oil Palm Phenolics Inhibit the Aggregation of -Amyloid Peptide into Oligomeric Complexes.

Int J Alzheimers Dis

2018
,

7608038

(
2018
).

PubMed

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2018

Cao, Jicong, de la Fuente-Nunez, Cesar, Lu, Timothy K, Ou, Rui Wen, Pande, Santosh G, Sinskey, Anthony J, Torres, Marcelo Der Torossian.

Yeast-Based Synthetic Biology Platform for Antimicrobial Peptide Production.

ACS Synth Biol

7
,

896-902

(
2018
).

PubMed

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2018

Miller, Charles, Ranganathan, Balu, Sinskey, Anthony.

Biocompatible Synthetic and Semi-synthetic Polymers – A Patent Analysis.

Pharm Nanotechnol

6
,

28-37

(
2018
).

PubMed

DOI

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2017

Brown, Alexander, Buyel, Johannes F, Cao, Jicong, Chen, William, Hermann, Mario, Kallweit, Eric, Kastilan, Robin, Lowenhaupt, Ky, Lu, Timothy K, Opdensteinen, Patrick, Perez-Pinera, Pablo, Purcell, Oliver, Sinskey, Anthony J, Tenhaef, Niklas.

Production of Functional Anti-Ebola Antibodies in Pichia pastoris.

ACS Synth Biol

6
,

2183-2190

(
2017
).

PubMed

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2017

Brigham, Christopher J, Rha, ChoKyun, Sinskey, Anthony J, Speth, Daan R.

Correction for Brigham et al., “Whole-Genome Microarray and Gene Deletion Studies Reveal Regulation of the Polyhydroxyalkanoate Production Cycle by the Stringent Response in Ralstonia eutropha H16”.

Appl Environ Microbiol

83
,

(
2017
).

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2017

Gorret, Nathalie, Grousseau, Estelle, Guillouet, Stéphane E, Lombard, Eric, Marc, Jillian, Sinskey, Anthony J.

Over expression of GroESL in Cupriavidus necator for heterotrophic and autotrophic isopropanol production.

Metab Eng

42
,

74-84

(
2017
).

PubMed

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2017

Borisova, Marina, Brigham, Christopher J, Jendrossek, Dieter, Juengert, Janina R, Mayer, Christoph, Sinskey, Anthony J, Wolz, Christiane.

Absence of ppGpp Leads to Increased Mobilization of Intermediately Accumulated Poly(3-Hydroxybutyrate) in Ralstonia eutropha H16.

Appl Environ Microbiol

83
,

(
2017
).

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2017

Bernardi, Amanda C, Brigham, Christopher J, Gai, Claudia S, Lu, Jingnan, Sinskey, Anthony J.

Corrigendum to “Experimental evolution and gene knockout studies reveal AcrA-mediated isobutanol tolerance in Ralstonia eutropha” [J Biosci Bioeng 122 (2016) 64-69].

J Biosci Bioeng

123
,

658

(
2017
).

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2016

Barone, P W, Bellisario, A, Cooney, C L, Natesan, S, Sharp, P A, Sinskey, A J, Springs, S L, Stewart, S R.

Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation.

Clin Pharmacol Ther

100
,

647-653

(
2016
).

PubMed

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2016

Bernardi, Amanda C, Brigham, Christopher J, Gai, Claudia S, Lu, Jingnan, Sinskey, Anthony J.

Experimental evolution and gene knockout studies reveal AcrA-mediated isobutanol tolerance in Ralstonia eutropha.

J Biosci Bioeng

122
,

64-9

(
2016
).

PubMed

DOI

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2016

Li, Youyuan, Plassmeier, Jens, Rueckert, Christian, Sinskey, Anthony J.

Metabolic engineering Corynebacterium glutamicum to produce triacylglycerols.

Metab Eng

33
,

86-97

(
2016
).

PubMed

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2015

Anthony Debono, C, Kurosawa, Kazuhiko, Sinskey, Anthony J.

Lignocellulose-derived inhibitors improve lipid extraction from wet Rhodococcus opacus cells.

Bioresour Technol

193
,

206-12

(
2015
).

PubMed

DOI

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2015

Kurosawa, Kazuhiko, Laser, Josephine, Sinskey, Anthony J.

Tolerance and adaptive evolution of triacylglycerol-producing Rhodococcus opacus to lignocellulose-derived inhibitors.

Biotechnol Biofuels

8
,

76

(
2015
).

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2015

Caravan, Peter, Day, Helen, DePeralta, Danielle K, Farrar, Christian T, Fuchs, Bryan C, Keil, Boris, Lauwers, Gregory Y, Rietz, Tyson A, Sinskey, Anthony J, Subramaniam, Arun, Tanabe, Kenneth K, Wei, Lan.

3D molecular MR imaging of liver fibrosis and response to rapamycin therapy in a bile duct ligation rat model.

J Hepatol

63
,

689-96

(
2015
).

PubMed

DOI

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2015

Kalinowski, Jörn, Kurosawa, Kazuhiko, Plassmeier, Jens, Rückert, Christian, Sinskey, Anthony J.

Engineering L-arabinose metabolism in triacylglycerol-producing Rhodococcus opacus for lignocellulosic fuel production.

Metab Eng

30
,

89-95

(
2015
).

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2015

Kurosawa, Kazuhiko, Plassmeier, Jens K, Radek, Andreas, Sinskey, Anthony J.

Improved glycerol utilization by a triacylglycerol-producing Rhodococcus opacus strain for renewable fuels.

Biotechnol Biofuels

8
,

31

(
2015
).

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2015

Brigham, Christopher J, Lu, Jingnan, Plassmeier, Jens K, Sinskey, Anthony J.

Characterization and modification of enzymes in the 2-ketoisovalerate biosynthesis pathway of Ralstonia eutropha H16.

Appl Microbiol Biotechnol

99
,

761-74

(
2015
).

PubMed

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2015

Gorret, Nathalie, Grousseau, Estelle, Grunwald, Stephan, Guillouet, Stéphane E, Mottet, Alexis, Plassmeier, Jens K, Popović, Milan K, Sinskey, Anthony, Uribelarrea, Jean-Louis.

Kinetic and stoichiometric characterization of organoautotrophic growth of Ralstonia eutropha on formic acid in fed-batch and continuous cultures.

Microb Biotechnol

8
,

155-63

(
2015
).

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2014

Bernardi, Amanda C, Brigham, Christopher J, Gai, Claudia S, Lu, Jingnan, Sinskey, Anthony J.

Insights into bacterial CO2 metabolism revealed by the characterization of four carbonic anhydrases in Ralstonia eutropha H16.

AMB Express

4
,

2

(
2014
).

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2014

Brigham, Christopher J, Jeon, Jong-Min, Kim, Hyun-Joong, Kim, Hyungsup, Kim, Yong-Hyun, Rha, ChoKyun, Sinskey, Anthony J, Yang, Yung-Hun, Yi, Da-Hye.

Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-co-HHx)) from butyrate using engineered Ralstonia eutropha.

Appl Microbiol Biotechnol

98
,

5461-9

(
2014
).

PubMed

DOI

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2014

Gorret, Nathalie, Grousseau, Estelle, Guillouet, Stéphane E, Lu, Jingnan, Sinskey, Anthony J.

Isopropanol production with engineered Cupriavidus necator as bioproduction platform.

Appl Microbiol Biotechnol

98
,

4277-90

(
2014
).

PubMed

DOI

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2013

Brigham, Christopher J, Lu, Jingnan, Rha, ChoKyun, Sinskey, Anthony J.

Characterization of an extracellular lipase and its chaperone from Ralstonia eutropha H16.

Appl Microbiol Biotechnol

97
,

2443-54

(
2013
).

PubMed

DOI

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2013

Bader, Johannes, Brigham, Christopher J, Budde, Charles F, Rha, ChoKyun, Riedel, Sebastian L, Sinskey, Anthony J, Stahl, Ulf.

Recovery of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from Ralstonia eutropha cultures with non-halogenated solvents.

Biotechnol Bioeng

110
,

461-70

(
2013
).

PubMed

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2013

Brigham, Christopher J, Kalacheva, Galina S, Sinskey, Anthony J, Volova, Tatiana G, Zhila, Natalia O.

Effects of intracellular poly(3-hydroxybutyrate) reserves on physiological-biochemical properties and growth of Ralstonia eutropha.

Res Microbiol

164
,

164-71

(
2013
).

PubMed

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2013

Kuzmina, A M, Murueva, A V, Shishatskaya, E I, Sinskey, A J, Volova, T G.

Microparticles prepared from biodegradable polyhydroxyalkanoates as matrix for encapsulation of cytostatic drug.

J Mater Sci Mater Med

24
,

1905-15

(
2013
).

PubMed

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2013

Kurosawa, Kazuhiko, Sinskey, Anthony J, Wewetzer, Sandra J.

Engineering xylose metabolism in triacylglycerol-producing Rhodococcus opacus for lignocellulosic fuel production.

Biotechnol Biofuels

6
,

134

(
2013
).

PubMed

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2013

MacEachran, Daniel P, Sinskey, Anthony J.

The Rhodococcus opacus TadD protein mediates triacylglycerol metabolism by regulating intracellular NAD(P)H pools.

Microb Cell Fact

12
,

104

(
2013
).

PubMed

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2013

Caravan, Peter, Fuchs, Bryan C, Lauwers, Gregory Y, Parkar, Ashfaq, Polasek, Miloslav, Schühle, Daniel T, Sinskey, Anthony J, Tanabe, Kenneth K, Wang, Huifang, Wei, Lan, Yang, Yan.

Molecular MRI of collagen to diagnose and stage liver fibrosis.

J Hepatol

59
,

992-8

(
2013
).

PubMed

DOI

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2012

Brigham, Christopher J, Rha, ChoKyun, Sinskey, Anthony J, Speth, Daan R.

Whole-genome microarray and gene deletion studies reveal regulation of the polyhydroxyalkanoate production cycle by the stringent response in Ralstonia eutropha H16.

Appl Environ Microbiol

78
,

8033-44

(
2012
).

PubMed

DOI

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2012

Bader, Johannes, Brigham, Christopher J, Budde, Charles F, Rha, ChoKyun, Riedel, Sebastian L, Sinskey, Anthony J, Yusof, Zainal Abidin Mohd.

Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by Ralstonia eutropha in high cell density palm oil fermentations.

Biotechnol Bioeng

109
,

74-83

(
2012
).

PubMed

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2012

Brigham, Christopher J, Reimer, Esther N, Rha, ChoKyun, Sinskey, Anthony J.

Examination of PHB Depolymerases in Ralstonia eutropha: Further Elucidation of the Roles of Enzymes in PHB Homeostasis.

AMB Express

2
,

26

(
2012
).

PubMed

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2012

Brigham, Christopher J, Rha, ChoKyun, Sinskey, Anthony J, Sudesh, Kumar, Wong, Yoke-Ming.

Biosynthesis and characterization of polyhydroxyalkanoate containing high 3-hydroxyhexanoate monomer fraction from crude palm kernel oil by recombinant Cupriavidus necator.

Bioresour Technol

121
,

320-7

(
2012
).

PubMed

DOI

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2012

Brigham, C J, Jeon, J-M, Rha, C K, Sinskey, A J, Song, E, Yang, Y-H.

Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) containing a predominant amount of 3-hydroxyvalerate by engineered Escherichia coli expressing propionate-CoA transferase.

J Appl Microbiol

113
,

815-23

(
2012
).

PubMed

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2012

Brigham, Christopher J, Gai, Claudia S, Lu, Jingnan, Sinskey, Anthony J.

Studies on the production of branched-chain alcohols in engineered Ralstonia eutropha.

Appl Microbiol Biotechnol

96
,

283-97

(
2012
).

PubMed

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2012

Brigham, Christopher J, Cho, Mimi, Sinskey, Anthony J, Stubbe, Joanne.

Purification of polyhydroxybutyrate synthase from its native organism, Ralstonia eutropha: implications for the initiation and elongation of polymer formation in vivo.

Biochemistry

51
,

2276-88

(
2012
).

PubMed

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2012

Brigham, Christopher J, Gohda, Aoi, Matsumoto, Ken’ichiro, Sinskey, Anthony J, Song, Yuyang, Taguchi, Seiichi, Yamada, Miwa.

Engineered Corynebacterium glutamicum as an endotoxin-free platform strain for lactate-based polyester production.

Appl Microbiol Biotechnol

93
,

1917-25

(
2012
).

PubMed

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2012

Brigham, Christopher J, Shishatskaya, Ekaterina, Sinskey, Anthony J, Volova, Tatiana G, Zhila, Natalia.

Manipulation of Ralstonia eutropha carbon storage pathways to produce useful bio-based products.

Subcell Biochem

64
,

343-66

(
2012
).

PubMed

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2011

Abeywardena, Mahinda, Fairus, Syed, Hayes, Kenneth C, Leow, Soon-Sen, Rha, ChoKyun, Sambandan, T G, Sambanthamurthi, Ravigadevi, Sekaran, Shamala Devi, Sinskey, Anthony J, Subramaniam, Krishnan, Sundram, Kalyana, Tan, YewAi, Wahid, Mohd Basri.

Positive outcomes of oil palm phenolics on degenerative diseases in animal models.

Br J Nutr

106
,

1664-75

(
2011
).

PubMed

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2011

Abeywardena, Mahinda, Hayes, Kenneth C, Leow, Soon-Sen, Rha, ChoKyun, Sambandan, T G, Sambanthamurthi, Ravigadevi, Sinskey, Anthony J, Subramaniam, Krishnan, Sundram, Kalyana, Tan, YewAi, Wahid, Mohd Basri.

Oil palm vegetation liquor: a new source of phenolic bioactives.

Br J Nutr

106
,

1655-63

(
2011
).

PubMed

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2011

Budde, Charles F, Rha, ChoKyun, Riedel, Sebastian L, Sinskey, Anthony J, Willis, Laura B.

Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from plant oil by engineered Ralstonia eutropha strains.

Appl Environ Microbiol

77
,

2847-54

(
2011
).

PubMed

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2011

Budde, Charles F, Hübner, Florian, Popović, Milan K, Rha, ChoKyun, Riedel, Sebastian L, Risch, Stefan, Sinskey, Anthony J.

Growth and polyhydroxybutyrate production by Ralstonia eutropha in emulsified plant oil medium.

Appl Microbiol Biotechnol

89
,

1611-9

(
2011
).

PubMed

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2011

Brigham, Christopher, Rha, ChoKyun, Sinskey, Anthony, Willis, Laura, Yang, Yung-Hun.

Improved detergent-based recovery of polyhydroxyalkanoates (PHAs).

Biotechnol Lett

33
,

937-42

(
2011
).

PubMed

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2011

Bhubalan, Kesaven, Brigham, Christopher J, Chuah, Jo-Ann, Rha, ChoKyun, Shozui, Fumi, Sinskey, Anthony J, Sudesh, Kumar, Taguchi, Seiichi.

Characterization of the highly active polyhydroxyalkanoate synthase of Chromobacterium sp. strain USM2.

Appl Environ Microbiol

77
,

2926-33

(
2011
).

PubMed

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2011

Kalacheva, G S, Sinskey, A J, Sokolenko, V A, Volova, T G, Zhila, N O.

[Synthesis of 3-hydroxybutyrate-CO-4-hydroxybutyrate copolymers by hydrogen-oxidizing bacteria].

Prikl Biokhim Mikrobiol

47
,

544-50

(
2011
).

PubMed

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2011

Boccazzi, Paolo, Lee, Kevin S, Ram, Rajeev J, Sinskey, Anthony J.

Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture.

Lab Chip

11
,

1730-9

(
2011
).

PubMed

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2011

Abeel, Thomas, Affourtit, Jason P, Birren, Bruce W, Dancel, Christine, DeBono, Anthony C, Desany, Brian, Desjardins, Christopher A, Gevers, Dirk, Ghiviriga, Ion, Godfrey, Paul A, Holder, Jason W, Kodira, Chinnappa D, Leach, Alex L B, Sinskey, Anthony J, Ulrich, Jil C, Zeng, Qiandong, Zucker, Jeremy.

Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development.

PLoS Genet

7
,

e1002219

(
2011
).

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2010

Brigham, Christopher J, Budde, Charles F, Holder, Jason W, Mahan, Alison E, Rha, ChoKyun, Sinskey, Anthony J, Zeng, Qiandong.

Elucidation of beta-oxidation pathways in Ralstonia eutropha H16 by examination of global gene expression.

J Bacteriol

192
,

5454-64

(
2010
).

PubMed

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2010

Boccazzi, Paolo, Brigham, Christopher J, Budde, Charles F, Hassan, Mohd Ali, Rha, ChoKyun, Sinskey, Anthony J, Willis, Laura B, Yang, Yung-Hun, Yusof, Zainal Abidin Mohd.

Optimization of growth media components for polyhydroxyalkanoate (PHA) production from organic acids by Ralstonia eutropha.

Appl Microbiol Biotechnol

87
,

2037-45

(
2010
).

PubMed

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2010

Budde, Charles F, Lu, Jingnan, Mahan, Alison E, Rha, ChoKyun, Sinskey, Anthony J.

Roles of multiple acetoacetyl coenzyme A reductases in polyhydroxybutyrate biosynthesis in Ralstonia eutropha H16.

J Bacteriol

192
,

5319-28

(
2010
).

PubMed

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2010

Archer, John A C, Boccazzi, Paolo, Cahill, Matt J, Capri, Ettore, Lessard, Philip A, Puglisi, Edoardo, Sinskey, Anthony J.

Transcriptional response of Rhodococcus aetherivorans I24 to polychlorinated biphenyl-contaminated sediments.

Microb Ecol

60
,

505-15

(
2010
).

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