Publications

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I
Zupke, C., Sinskey, A. J. & Stephanopoulos, G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol 44, 27-36 (1995).
Ulmer, K. M., Gomez, R. F. & Sinskey, A. J. Ionizing radiation damage to the folded chromosome of Escherichia coli K-12: sedimentation properties of irradiated nucleoids and chromosomal deoxyribonucleic acid. J Bacteriol 138, 475-85 (1979).
Ulmer, K. M., Gomez, R. F. & Sinskey, A. J. Ionizing radiation damage to the folded chromosome of Escherichia coli K-12: repair of double-strand breaks in deoxyribonucleic acid. J Bacteriol 138, 486-91 (1979).
Treadway, S. L. et al. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Appl Microbiol Biotechnol 51, 786-93 (1999).
Easson, D. D., Sinskey, A. J. & Peoples, O. P. Isolation of Zoogloea ramigera I-16-M exopolysaccharide biosynthetic genes and evidence for instability within this region. J Bacteriol 169, 4518-24 (1987).
Grousseau, E., Lu, J., Gorret, N., Guillouet, S. E. & Sinskey, A. J. Isopropanol production with engineered Cupriavidus necator as bioproduction platform. Appl Microbiol Biotechnol 98, 4277-90 (2014).
K
Grunwald, S. et al. Kinetic and stoichiometric characterization of organoautotrophic growth of Ralstonia eutropha on formic acid in fed-batch and continuous cultures. Microb Biotechnol 8, 155-63 (2015).
Tian, J., Sinskey, A. J. & Stubbe, J. Kinetic studies of polyhydroxybutyrate granule formation in Wautersia eutropha H16 by transmission electron microscopy. J Bacteriol 187, 3814-24 (2005).
Giard, D. J., Fleischaker, R. J. & Sinskey, A. J. Kinetics of human beta interferon production under different temperature conditions. J Interferon Res 2, 471-7 (1982).
Pellon, J. R., Sinskey, A. J., Hecht, S. M. & Gomez, R. F. Kinetics of the bleomycin A2 damage in vivo to the folded chromosome of Escherichia coli. Chem Biol Interact 43, 245-51 (1983).
L
Glacken, M. W., Fleischaker, R. J. & Sinskey, A. J. Large-scale production of mammalian cells and their products: engineering principles and barriers to scale-up. Ann N Y Acad Sci 413, 355-72 (1983).
Stewart, S. R. et al. Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation. Clin Pharmacol Ther 100, 647-653 (2016).
Kurosawa, K., C Debono, A. & Sinskey, A. J. Lignocellulose-derived inhibitors improve lipid extraction from wet Rhodococcus opacus cells. Bioresour Technol 193, 206-12 (2015).
Jia, Y., Kappock, T. J., Frick, T., Sinskey, A. J. & Stubbe, J. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase. Biochemistry 39, 3927-36 (2000).
M
Lessard, P. A., Kulaveerasingam, H., York, G. M., Strong, A. & Sinskey, A. J. Manipulating gene expression for the metabolic engineering of plants. Metab Eng 4, 67-79 (2002).
Brigham, C. J., Zhila, N., Shishatskaya, E., Volova, T. G. & Sinskey, A. J. Manipulation of Ralstonia eutropha carbon storage pathways to produce useful bio-based products. Subcell Biochem 64, 343-66 (2012).
Glacken, M. W., Adema, E. & Sinskey, A. J. Mathematical descriptions of hybridoma culture kinetics: I. Initial metabolic rates. Biotechnol Bioeng 32, 491-506 (1988).
Glacken, M. W., Adema, E. & Sinskey, A. J. Mathematical descriptions of hybridoma culture kinetics: II. The relationship between thiol chemistry and the degradation of serum activity. Biotechnol Bioeng 33, 440-50 (1989).
Montville, T. J., Cooney, C. L. & Sinskey, A. J. Measurement and synthesis of insoluble and soluble dextran by Streptococcus mutans. J Dent Res 56, 983-9 (1977).
Hwang, C., Lodish, H. F. & Sinskey, A. J. Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells. Methods Enzymol 251, 212-21 (1995).
Thompson, S. et al. Mechanistic studies on beta-ketoacyl thiolase from Zoogloea ramigera: identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild-type and mutant enzymes. Biochemistry 28, 5735-42 (1989).
Jia, Y. et al. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry 40, 1011-9 (2001).
Zanzotto, A. et al. Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnol Bioeng 87, 243-54 (2004).
Park, S. M., Sinskey, A. J. & Stephanopoulos, G. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnol Bioeng 55, 864-79 (1997).
Plassmeier, J., Li, Y., Rueckert, C. & Sinskey, A. J. Metabolic engineering Corynebacterium glutamicum to produce triacylglycerols. Metab Eng 33, 86-97 (2016).
Jetten, M. S., Follettie, M. T. & Sinskey, A. J. Metabolic engineering of Corynebacterium glutamicum. Ann N Y Acad Sci 721, 12-29 (1994).
Stephanopoulos, G. & Sinskey, A. J. Metabolic engineering--methodologies and future prospects. Trends Biotechnol 11, 392-6 (1993).
Guillouet, S. et al. Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine-overproducing Corynebacterium glutamicum. Appl Microbiol Biotechnol 57, 667-73 (2001).
Park, S. M., Klapa, M. I., Sinskey, A. J. & Stephanopoulos, G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol Bioeng 62, 392-401 (1999).
Klapa, M. I., Park, S. M., Sinskey, A. J. & Stephanopoulos, G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol Bioeng 62, 375-391 (1999).
Morhart, R. E., Mata, L. J., Sinskey, A. J. & Harris, R. S. A microbiological and biochemical study of gingival crevice debris obtained from Guatemalan Mayan Indians. J Periodontol 41, 644-9 (1970).
Lee, H. L. T., Boccazzi, P., Ram, R. J. & Sinskey, A. J. Microbioreactor arrays with integrated mixers and fluid injectors for high-throughput experimentation with pH and dissolved oxygen control. Lab Chip 6, 1229-35 (2006).
Zhang, Z. et al. Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. Lab Chip 6, 906-13 (2006).
Lee, K. S., Boccazzi, P., Sinskey, A. J. & Ram, R. J. Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture. Lab Chip 11, 1730-9 (2011).
Murueva, A. V., Shishatskaya, E. I., Kuzmina, A. M., Volova, T. G. & Sinskey, A. J. Microparticles prepared from biodegradable polyhydroxyalkanoates as matrix for encapsulation of cytostatic drug. J Mater Sci Mater Med 24, 1905-15 (2013).
Gomez, R. F., Sinskey, A. J., Davies, R. & Labuza, T. P. Minimal medium recovery of heated Salmonella typhimurium LT2. J Gen Microbiol 74, 267-74 (1973).
Shelikoff, M., Sinskey, A. J. & Stephanopoulos, G. A modeling framework for the study of protein glycosylation. Biotechnol Bioeng 50, 73-90 (1996).
Follettie, M. T. & Sinskey, A. J. Molecular cloning and nucleotide sequence of the Corynebacterium glutamicum pheA gene. J Bacteriol 167, 695-702 (1986).
von der Osten, C. H., Barbas, C. F., Wong, C. H. & Sinskey, A. J. Molecular cloning, nucleotide sequence and fine-structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1,6-biphosphate aldolase to class I and class II aldolases. Mol Microbiol 3, 1625-37 (1989).
von der Osten, C. H. et al. Molecular cloning of aldolases for synthetic applications. Ann N Y Acad Sci 613, 771-5 (1990).
Fuchs, B. C. et al. Molecular MRI of collagen to diagnose and stage liver fibrosis. J Hepatol 59, 992-8 (2013).
Han, K. S., Archer, J. A. & Sinskey, A. J. The molecular structure of the Corynebacterium glutamicum threonine synthase gene. Mol Microbiol 4, 1693-702 (1990).
Jamas, S., Rha, C. & Sinskey, A. J. Morphology of yeast cell wall as affected by genetic manipulation of beta(1 --> 6) glycosidic linkage. Biotechnol Bioeng 28, 769-84 (1986).
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Zapatka, F. A., Varney, G. W. & Sinskey, A. J. Neutralization of the bactericidal effect of cocoa powder on salmonellae by casein. J Appl Bacteriol 42, 21-5 (1977).
York, G. M., Stubbe, J. & Sinskey, A. J. New insight into the role of the PhaP phasin of Ralstonia eutropha in promoting synthesis of polyhydroxybutyrate. J Bacteriol 183, 2394-7 (2001).
Imada, A., Sinskey, A. J. & Tannenbaum, S. R. A new macromolecular inhibitor of yeast ribonuclease mediated through purine nucleotides. Biochim Biophys Acta 268, 674-9 (1972).
Maul, S. B., Sinskey, A. J. & Tannenbaum, S. R. New process for reducing the nucleic acid content of yeast. Nature 228, 181 (1970).
Tannenbaum, S. R., Sinskey, A. J., Weisman, M. & Bishop, W. Nitrite in human saliva. Its possible relationship to nitrosamine formation. J Natl Cancer Inst 53, 79-84 (1974).
Stubbe, J. et al. Nontemplate-dependent polymerization processes: polyhydroxyalkanoate synthases as a paradigm. Annu Rev Biochem 74, 433-80 (2005).
Peoples, O. P. et al. Nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum hom-thrB operon. Mol Microbiol 2, 63-72 (1988).

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