Publications

Export 215 results:
Author Title Type [ Year(Desc)]
1995
Chen, K., Stephanopoulos, G. N., Sinskey, A. J. & Lodish, H. F. Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3. Biotechnology (N Y) 13, 1191-7 (1995).
1996
Shelikoff, M., Sinskey, A. J. & Stephanopoulos, G. A modeling framework for the study of protein glycosylation. Biotechnol Bioeng 50, 73-90 (1996).
1997
Chung, J. D., Zabel, C., Sinskey, A. J. & Stephanopoulos, G. Extension of Sp2/0 hybridoma cell viability through interleukin-6 supplementation. Biotechnol Bioeng 55, 439-46 (1997).
Park, S. M., Sinskey, A. J. & Stephanopoulos, G. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnol Bioeng 55, 864-79 (1997).
Sim, S. J. et al. PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo. Nat Biotechnol 15, 63-7 (1997).
1998
Chung, J. D., Sinskey, A. J. & Stephanopoulos, G. Growth factor and bcl-2 mediated survival during abortive proliferation of hybridoma cell line. Biotechnol Bioeng 57, 164-71 (1998).
Koffas, M. A., Ramamoorthi, R., Pine, W. A., Sinskey, A. J. & Stephanopoulos, G. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene. Appl Microbiol Biotechnol 50, 346-52 (1998).
1999
Goswami, J., Sinskey, A. J., Steller, H., Stephanopoulos, G. N. & Wang, D. I. Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnol Bioeng 62, 632-40 (1999).
Lessard, P. A., O'Brien, X. M., Ahlgren, N. A., Ribich, S. A. & Sinskey, A. J. Characterization of IS1676 from Rhodococcus erythropolis SQ1. Appl Microbiol Biotechnol 52, 811-9 (1999).
Guillouet, S., Rodal, A. A., An, G., Lessard, P. A. & Sinskey, A. J. Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production. Appl Environ Microbiol 65, 3100-7 (1999).
Shaw-Reid, C. A., McCormick, M. M., Sinskey, A. J. & Stephanopoulos, G. Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum. Appl Microbiol Biotechnol 51, 325-33 (1999).
Treadway, S. L. et al. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Appl Microbiol Biotechnol 51, 786-93 (1999).
Park, S. M., Klapa, M. I., Sinskey, A. J. & Stephanopoulos, G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol Bioeng 62, 392-401 (1999).
Klapa, M. I., Park, S. M., Sinskey, A. J. & Stephanopoulos, G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol Bioeng 62, 375-391 (1999).
Müh, U., Sinskey, A. J., Kirby, D. P., Lane, W. S. & Stubbe, J. PHA synthase from chromatium vinosum: cysteine 149 is involved in covalent catalysis. Biochemistry 38, 826-37 (1999).
An, G. H., Song, K. B. & Sinskey, A. J. Redirection of carbon flux to lysine in a recombinant of Corynebacterium lactofermentum ATCC 21799 by limited supply of pantothenate. J Biosci Bioeng 88, 168-72 (1999).
2000
Jia, Y., Kappock, T. J., Frick, T., Sinskey, A. J. & Stubbe, J. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase. Biochemistry 39, 3927-36 (2000).
2001
York, G. M., Junker, B. H., Stubbe, J. A. & Sinskey, A. J. Accumulation of the PhaP phasin of Ralstonia eutropha is dependent on production of polyhydroxybutyrate in cells. J Bacteriol 183, 4217-26 (2001).
Yanagimachi, K. S. et al. Application of radiolabeled tracers to biocatalytic flux analysis. Eur J Biochem 268, 4950-60 (2001).
Yuan, W. et al. Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. Arch Biochem Biophys 394, 87-98 (2001).
Loos, A. et al. Development and validation of corynebacterium DNA microarrays. Appl Environ Microbiol 67, 2310-8 (2001).
Jia, Y. et al. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry 40, 1011-9 (2001).
Guillouet, S. et al. Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine-overproducing Corynebacterium glutamicum. Appl Microbiol Biotechnol 57, 667-73 (2001).
York, G. M., Stubbe, J. & Sinskey, A. J. New insight into the role of the PhaP phasin of Ralstonia eutropha in promoting synthesis of polyhydroxybutyrate. J Bacteriol 183, 2394-7 (2001).
2002
O'Brien, X. M., Parker, J. A., Lessard, P. A. & Sinskey, A. J. Engineering an indene bioconversion process for the production of cis-aminoindanol: a model system for the production of chiral synthons. Appl Microbiol Biotechnol 59, 389-99 (2002).
Lessard, P. A., Kulaveerasingam, H., York, G. M., Strong, A. & Sinskey, A. J. Manipulating gene expression for the metabolic engineering of plants. Metab Eng 4, 67-79 (2002).
Stafford, D. E. et al. Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proc Natl Acad Sci U S A 99, 1801-6 (2002).
York, G. M., Stubbe, J. & Sinskey, A. J. The Ralstonia eutropha PhaR protein couples synthesis of the PhaP phasin to the presence of polyhydroxybutyrate in cells and promotes polyhydroxybutyrate production. J Bacteriol 184, 59-66 (2002).
2003
Glanemann, C. et al. Disparity between changes in mRNA abundance and enzyme activity in Corynebacterium glutamicum: implications for DNA microarray analysis. Appl Microbiol Biotechnol 61, 61-8 (2003).
Coldren, C. D. et al. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med 69, 725-32 (2003).
Osman, A. et al. Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms. Plant Physiol 131, 1294-301 (2003).
Nielsen, U. B., Cardone, M. H., Sinskey, A. J., MacBeath, G. & Sorger, P. K. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A 100, 9330-5 (2003).
York, G. M. et al. Ralstonia eutropha H16 encodes two and possibly three intracellular Poly[D-(-)-3-hydroxybutyrate] depolymerase genes. J Bacteriol 185, 3788-94 (2003).
2004
Gorret, N. et al. Bioreactor culture of oil palm (Elaeis guineensis) and effects of nitrogen source, inoculum size, and conditioned medium on biomass production. J Biotechnol 108, 253-63 (2004).
Priefert, H. et al. Indene bioconversion by a toluene inducible dioxygenase of Rhodococcus sp. I24. Appl Microbiol Biotechnol 65, 168-76 (2004).
Zanzotto, A. et al. Membrane-aerated microbioreactor for high-throughput bioprocessing. Biotechnol Bioeng 87, 243-54 (2004).
Lessard, P. A., O'Brien, X. M., Currie, D. H. & Sinskey, A. J. pB264, a small, mobilizable, temperature sensitive plasmid from Rhodococcus. BMC Microbiol 4, 15 (2004).
Ozminkowski, R. J. et al. The use of disease-modifying new drugs for multiple sclerosis treatment in private-sector health plans. Clin Ther 26, 1341-54 (2004).
2005
Tian, J. et al. Analysis of transient polyhydroxybutyrate production in Wautersia eutropha H16 by quantitative Western analysis and transmission electron microscopy. J Bacteriol 187, 3825-32 (2005).
Tian, J., Sinskey, A. J. & Stubbe, J. Class III polyhydroxybutyrate synthase: involvement in chain termination and reinitiation. Biochemistry 44, 8369-77 (2005).
Tian, J., Sinskey, A. J. & Stubbe, J. Detection of intermediates from the polymerization reaction catalyzed by a D302A mutant of class III polyhydroxyalkanoate (PHA) synthase. Biochemistry 44, 1495-503 (2005).
Szita, N. et al. Development of a multiplexed microbioreactor system for high-throughput bioprocessing. Lab Chip 5, 819-26 (2005).
Boccazzi, P. et al. Gene expression analysis of Escherichia coli grown in miniaturized bioreactor platforms for high-throughput analysis of growth and genomic data. Appl Microbiol Biotechnol 68, 518-32 (2005).
Lawrence, A. G., Choi, J., Rha, C. K., Stubbe, J. & Sinskey, A. J. In vitro analysis of the chain termination reaction in the synthesis of poly-(R)-beta-hydroxybutyrate by the class III synthase from Allochromatium vinosum. Biomacromolecules 6, 2113-9 (2005).
Tian, J., Sinskey, A. J. & Stubbe, J. Kinetic studies of polyhydroxybutyrate granule formation in Wautersia eutropha H16 by transmission electron microscopy. J Bacteriol 187, 3814-24 (2005).
Stubbe, J. et al. Nontemplate-dependent polymerization processes: polyhydroxyalkanoate synthases as a paradigm. Annu Rev Biochem 74, 433-80 (2005).
Lawrence, A. G. et al. Transcriptional analysis of Ralstonia eutropha genes related to poly-(R)-3-hydroxybutyrate homeostasis during batch fermentation. Appl Microbiol Biotechnol 68, 663-72 (2005).
2006
Kurosawa, K. et al. Characterization of Streptomyces MITKK-103, a newly isolated actinomycin X2-producer. Appl Microbiol Biotechnol 72, 145-154 (2006).
Boccazzi, P. et al. Differential gene expression profiles and real-time measurements of growth parameters in Saccharomyces cerevisiae grown in microliter-scale bioreactors equipped with internal stirring. Biotechnol Prog 22, 710-7 (2006).
Stallings, S. C. et al. A framework to evaluate the economic impact of pharmacogenomics. Pharmacogenomics 7, 853-62 (2006).

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