Publications

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2016
Stewart, S. R. et al. Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation. Clin Pharmacol Ther 100, 647-653 (2016).
2013
Murueva, A. V., Shishatskaya, E. I., Kuzmina, A. M., Volova, T. G. & Sinskey, A. J. Microparticles prepared from biodegradable polyhydroxyalkanoates as matrix for encapsulation of cytostatic drug. J Mater Sci Mater Med 24, 1905-15 (2013).
2012
Yang, Y. - H. et al. Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) containing a predominant amount of 3-hydroxyvalerate by engineered Escherichia coli expressing propionate-CoA transferase. J Appl Microbiol 113, 815-23 (2012).
2011
Volova, T. G., Zhila, N. O., Kalacheva, G. S., Sokolenko, V. A. & Sinskey, A. J. [Synthesis of 3-hydroxybutyrate-CO-4-hydroxybutyrate copolymers by hydrogen-oxidizing bacteria]. Prikl Biokhim Mikrobiol 47, 544-50 (2011).
2010
MacEachran, D. P., Prophete, M. E. & Sinskey, A. J. The Rhodococcus opacus PD630 heparin-binding hemagglutinin homolog TadA mediates lipid body formation. Appl Environ Microbiol 76, 7217-25 (2010).
2008
Abdullah, M. A., Rahmah, A. Ur, Sinskey, A. J. & Rha, C. K. Cell engineering and molecular pharming for biopharmaceuticals. Open Med Chem J 2, 49-61 (2008).
2006
Kurosawa, K. et al. Characterization of Streptomyces MITKK-103, a newly isolated actinomycin X2-producer. Appl Microbiol Biotechnol 72, 145-154 (2006).
Cho, C. W. et al. Glioblastoma cell death induced by asiatic acid. Cell Biol Toxicol 22, 393-408 (2006).
2003
Glanemann, C. et al. Disparity between changes in mRNA abundance and enzyme activity in Corynebacterium glutamicum: implications for DNA microarray analysis. Appl Microbiol Biotechnol 61, 61-8 (2003).
2002
O'Brien, X. M., Parker, J. A., Lessard, P. A. & Sinskey, A. J. Engineering an indene bioconversion process for the production of cis-aminoindanol: a model system for the production of chiral synthons. Appl Microbiol Biotechnol 59, 389-99 (2002).
2001
York, G. M., Junker, B. H., Stubbe, J. A. & Sinskey, A. J. Accumulation of the PhaP phasin of Ralstonia eutropha is dependent on production of polyhydroxybutyrate in cells. J Bacteriol 183, 4217-26 (2001).
Yanagimachi, K. S. et al. Application of radiolabeled tracers to biocatalytic flux analysis. Eur J Biochem 268, 4950-60 (2001).
Yuan, W. et al. Class I and III polyhydroxyalkanoate synthases from Ralstonia eutropha and Allochromatium vinosum: characterization and substrate specificity studies. Arch Biochem Biophys 394, 87-98 (2001).
Loos, A. et al. Development and validation of corynebacterium DNA microarrays. Appl Environ Microbiol 67, 2310-8 (2001).
Jia, Y. et al. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry 40, 1011-9 (2001).
Guillouet, S. et al. Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine-overproducing Corynebacterium glutamicum. Appl Microbiol Biotechnol 57, 667-73 (2001).
York, G. M., Stubbe, J. & Sinskey, A. J. New insight into the role of the PhaP phasin of Ralstonia eutropha in promoting synthesis of polyhydroxybutyrate. J Bacteriol 183, 2394-7 (2001).
2000
Jia, Y., Kappock, T. J., Frick, T., Sinskey, A. J. & Stubbe, J. Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in Chromatium vinosum PHB synthase. Biochemistry 39, 3927-36 (2000).
1999
Goswami, J., Sinskey, A. J., Steller, H., Stephanopoulos, G. N. & Wang, D. I. Apoptosis in batch cultures of Chinese hamster ovary cells. Biotechnol Bioeng 62, 632-40 (1999).
Lessard, P. A., O'Brien, X. M., Ahlgren, N. A., Ribich, S. A. & Sinskey, A. J. Characterization of IS1676 from Rhodococcus erythropolis SQ1. Appl Microbiol Biotechnol 52, 811-9 (1999).
Guillouet, S., Rodal, A. A., An, G., Lessard, P. A. & Sinskey, A. J. Expression of the Escherichia coli catabolic threonine dehydratase in Corynebacterium glutamicum and its effect on isoleucine production. Appl Environ Microbiol 65, 3100-7 (1999).
Shaw-Reid, C. A., McCormick, M. M., Sinskey, A. J. & Stephanopoulos, G. Flux through the tetrahydrodipicolinate succinylase pathway is dispensable for L-lysine production in Corynebacterium glutamicum. Appl Microbiol Biotechnol 51, 325-33 (1999).
Treadway, S. L. et al. Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24. Appl Microbiol Biotechnol 51, 786-93 (1999).
Park, S. M., Klapa, M. I., Sinskey, A. J. & Stephanopoulos, G. Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol Bioeng 62, 392-401 (1999).
Müh, U., Sinskey, A. J., Kirby, D. P., Lane, W. S. & Stubbe, J. PHA synthase from chromatium vinosum: cysteine 149 is involved in covalent catalysis. Biochemistry 38, 826-37 (1999).
An, G. H., Song, K. B. & Sinskey, A. J. Redirection of carbon flux to lysine in a recombinant of Corynebacterium lactofermentum ATCC 21799 by limited supply of pantothenate. J Biosci Bioeng 88, 168-72 (1999).
1998
Chung, J. D., Sinskey, A. J. & Stephanopoulos, G. Growth factor and bcl-2 mediated survival during abortive proliferation of hybridoma cell line. Biotechnol Bioeng 57, 164-71 (1998).
Koffas, M. A., Ramamoorthi, R., Pine, W. A., Sinskey, A. J. & Stephanopoulos, G. Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene. Appl Microbiol Biotechnol 50, 346-52 (1998).
1997
Chung, J. D., Zabel, C., Sinskey, A. J. & Stephanopoulos, G. Extension of Sp2/0 hybridoma cell viability through interleukin-6 supplementation. Biotechnol Bioeng 55, 439-46 (1997).
Park, S. M., Sinskey, A. J. & Stephanopoulos, G. Metabolic and physiological studies of Corynebacterium glutamicum mutants. Biotechnol Bioeng 55, 864-79 (1997).
Sim, S. J. et al. PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo. Nat Biotechnol 15, 63-7 (1997).
1996
Shelikoff, M., Sinskey, A. J. & Stephanopoulos, G. A modeling framework for the study of protein glycosylation. Biotechnol Bioeng 50, 73-90 (1996).
1995
Jetten, M. S., Follettie, M. T. & Sinskey, A. J. Effect of different levels of aspartokinase on the lysine production by Corynebacterium lactofermentum. Appl Microbiol Biotechnol 43, 76-82 (1995).
Colón, G. E. et al. Effect of inducible thrB expression on amino acid production in Corynebacterium lactofermentum ATCC 21799. Appl Environ Microbiol 61, 74-8 (1995).
Zupke, C., Sinskey, A. J. & Stephanopoulos, G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol 44, 27-36 (1995).
Hwang, C., Lodish, H. F. & Sinskey, A. J. Measurement of glutathione redox state in cytosol and secretory pathway of cultured cells. Methods Enzymol 251, 212-21 (1995).
Colón, G. E., Nguyen, T. T., Jetten, M. S., Sinskey, A. J. & Stephanopoulos, G. Production of isoleucine by overexpression of ilvA in a Corynebacterium lactofermentum threonine producer. Appl Microbiol Biotechnol 43, 482-8 (1995).
Jetten, M. S. & Sinskey, A. J. Purification and properties of oxaloacetate decarboxylase from Corynebacterium glutamicum. Antonie Van Leeuwenhoek 67, 221-7 (1995).
Jetten, M. S. & Sinskey, A. J. Recent advances in the physiology and genetics of amino acid-producing bacteria. Crit Rev Biotechnol 15, 73-103 (1995).
Chen, K., Stephanopoulos, G. N., Sinskey, A. J. & Lodish, H. F. Regulated secretion of prolactin by the mouse insulinoma cell line beta TC-3. Biotechnology (N Y) 13, 1191-7 (1995).
1994
Gubler, M., Jetten, M., Lee, S. H. & Sinskey, A. J. Cloning of the pyruvate kinase gene (pyk) of Corynebacterium glutamicum and site-specific inactivation of pyk in a lysine-producing Corynebacterium lactofermentum strain. Appl Environ Microbiol 60, 2494-500 (1994).
Shelikoff, M., Sinskey, A. J. & Stephanopoulos, G. The effect of protein synthesis inhibitors on the glycosylation site occupancy of recombinant human prolactin. Cytotechnology 15, 195-208 (1994).
Jetten, M. S., Follettie, M. T. & Sinskey, A. J. Metabolic engineering of Corynebacterium glutamicum. Ann N Y Acad Sci 721, 12-29 (1994).
Gerngross, T. U. et al. Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus: evidence for a required posttranslational modification for catalytic activity. Biochemistry 33, 9311-20 (1994).
Jetten, M. S., Gubler, M. E., Lee, S. H. & Sinskey, A. J. Structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum. Appl Environ Microbiol 60, 2501-7 (1994).
1993
Archer, J. A. & Sinskey, A. J. The DNA sequence and minimal replicon of the Corynebacterium glutamicum plasmid pSR1: evidence of a common ancestry with plasmids from C. diphtheriae. J Gen Microbiol 139, 1753-9 (1993).
Follettie, M. T., Peoples, O. P., Agoropoulou, C. & Sinskey, A. J. Gene structure and expression of the Corynebacterium flavum N13 ask-asd operon. J Bacteriol 175, 4096-103 (1993).
Gerngross, T. U., Reilly, P., Stubbe, J., Sinskey, A. J. & Peoples, O. P. Immunocytochemical analysis of poly-beta-hydroxybutyrate (PHB) synthase in Alcaligenes eutrophus H16: localization of the synthase enzyme at the surface of PHB granules. J Bacteriol 175, 5289-93 (1993).
Stephanopoulos, G. & Sinskey, A. J. Metabolic engineering--methodologies and future prospects. Trends Biotechnol 11, 392-6 (1993).
1992
Jain, J., Valge-Archer, V. E., Sinskey, A. J. & Rao, A. The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter. J Exp Med 175, 853-62 (1992).

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